multiplexing platform to simultaneously monitor various signaling events in living cells
Highly multiplex-able & massive parallel assay technology
Our core proprietary EXTassay technology provides a simultaneous analysis of multiple cellular targets and signaling events within living cells. All signaling events are captured by molecularly barcoded reporters, resulting in measurements of large data sets (virtually unlimited number of data points). The unmatcheddepth of the EXTassay technology enables to decode target specificity and cellular effector profiles within one experiment.
Highly sensitive, flexible & easy-to-use reporter assay
The proprietary splitSENSOR technology is a highly sensitive, flexible and easy-to-use reporter assay system to monitor various cellular events in living cells, including the activity of drug targets. Various cellular events, such as regulated protein-protein interactions, can be robustly and quantitatively measured both at the membrane and in the cytosol of the cell. This feature makes it, for example, an invaluable tool to assess the activity of receptors as measured by the regulated binding to their cognate cytosolic adapters. Therefore, this technology can be applied in particular to assess compound actions on drug targets, such as G protein-coupled receptors and receptor tyrosine kinases.
Genetically encoded tools for cell-based HTS