Pathway based Drug Discovery
Systasy leverages highly multiplexed pathway activity screens in combination with its patient-derived human disease models to understand complex disease pathways.
Systasy’s barcoding technology radically reduces experimental numbers and allows multiple features to be tracked in parallel, including signaling pathway activities, upstream targets, cellular identities, and experimental conditions.
It can be applied to any cell type to identify disease pathways and therapeutic targets as well to screen compound libraries and optimize lead compounds to bring diseased faulty pathways back in sync.
We are able to provide deep insights across the drug discovery pipeline –
Target Identification & Validation
- Identifying deregulated disease pathways
- Drug target deconvolution (phenotypic screening)
- Drug mechanism-of-action (MOA) analysis
Hit Identification & Optimization
- Highly-parallel combinatorial drug screening
- Hit ID and Hit to LEAD optimization
- Secondary targets and toxicity detection
Patient Stratification
- Focussed disease cohorts
- Drug dose-response-profiling
- Drug responders versus non-responder detection
Pathway-based compound screening enables highly improved target selection.
- Activities of currently up to 30 major cellular signaling pathways are captured in parallel using a ‘DNA barcoded‘ readout.
- Activity profiles are based on signaling sensors that are introduced into human neuronal 2D or 3 models or cell lines; murine models are available as well.
- Applicable to compound screening and validation purposes.
targetFinder
targetFINDER combines RNAi or CRISPR/Cas9 libraries with optimized sensors to measure the roles of individual genes in signaling networks.
pathwayPROFILER
pathwayPROFILER measures the activities of various disease-relevant target classes in living cells.
Collaboration is part of our DNA!
Ready to take your research to the next level? Contact us today to learn more about our services, pricing, and how we can help you achieve your scientific goals.
Ready to take your research to the next level? Contact us today to learn more about our services, pricing, and how we can help you achieve your scientific goals.